2018
Aurel T. Tankeu; Marcel Azabji-Kenfack; Chris-Nadège Nganou; Eliane Ngassam; Liliane Kuate-Mfeukeu; Camille Mba; Mesmin Y. Dehayem; Jean-Claude Mbanya; Eugene Sobngwi
Effect of propranolol on heart rate variability in hyperthyroidism Article de journal
Dans: BMC Research Notes, vol. 11, iss. 1, p. 151, 2018, ISSN: 1756-0500.
Résumé | Liens | BibTeX | Étiquettes: Effect, Heart rate variability, Hyperthyroidism, Propranolol
@article{Tankeu2018,
title = {Effect of propranolol on heart rate variability in hyperthyroidism},
author = {Aurel T. Tankeu and Marcel Azabji-Kenfack and Chris-Nadège Nganou and Eliane Ngassam and Liliane Kuate-Mfeukeu and Camille Mba and Mesmin Y. Dehayem and Jean-Claude Mbanya and Eugene Sobngwi},
url = {https://doi.org/10.1186/s13104-018-3224-x https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3224-x},
doi = {10.1186/s13104-018-3224-x},
issn = {1756-0500},
year = {2018},
date = {2018-01-01},
journal = {BMC Research Notes},
volume = {11},
issue = {1},
pages = {151},
publisher = {BioMed Central},
abstract = {Objectives: We aimed to determine the effect of propanolol on heart rate variability (HRV) in hyperthyroidism before antithyroid treatment. This was a before and after study, on ten patients presenting overt hyperthyroidism naïve to treatment. In each patient, a resting electrocardiogram was done followed by estimation of cardiac autonomic dysfunction during five maneuvers (Ewing battery tests). Long term HRV measurement was done using 24 h ambulatory electrocardiographic recording. This automatically provided estimation of HRV using SDNN and RMSSD index, LF, HF, and HF/LF ratio. After baseline investigations, 40 mg of propanolol was given twice a day for 3 days and same parameters were measured after 72 h of treatment. Results: Our patients were aged 40 ± 10 years. Propanolol significantly reduced RR and HR interval (669 ms vs 763 ms and 91 vs 79 bpm; p < 0.01). QT and PR space were significantly extended (360 vs 384 ms and 133 vs 172 ms; p = 0.01). It increases QRS complex and blood pressure response to sustained handgrip but failed to modify previously decreased heart response to deep breathing. HRV parameters such as SDNN, RMSSD, LF, HF and sympathovagal balance estimate by HF/LF ratio remained unchanged. Although a significant reduction in heart excitability, propanolol failed to restore a good sympathovagal balance in hyperthyroidism. Trial registration NCT03393728 "Retrospectively registered"},
keywords = {Effect, Heart rate variability, Hyperthyroidism, Propranolol},
pubstate = {published},
tppubtype = {article}
}
Objectives: We aimed to determine the effect of propanolol on heart rate variability (HRV) in hyperthyroidism before antithyroid treatment. This was a before and after study, on ten patients presenting overt hyperthyroidism naïve to treatment. In each patient, a resting electrocardiogram was done followed by estimation of cardiac autonomic dysfunction during five maneuvers (Ewing battery tests). Long term HRV measurement was done using 24 h ambulatory electrocardiographic recording. This automatically provided estimation of HRV using SDNN and RMSSD index, LF, HF, and HF/LF ratio. After baseline investigations, 40 mg of propanolol was given twice a day for 3 days and same parameters were measured after 72 h of treatment. Results: Our patients were aged 40 ± 10 years. Propanolol significantly reduced RR and HR interval (669 ms vs 763 ms and 91 vs 79 bpm; p < 0.01). QT and PR space were significantly extended (360 vs 384 ms and 133 vs 172 ms; p = 0.01). It increases QRS complex and blood pressure response to sustained handgrip but failed to modify previously decreased heart response to deep breathing. HRV parameters such as SDNN, RMSSD, LF, HF and sympathovagal balance estimate by HF/LF ratio remained unchanged. Although a significant reduction in heart excitability, propanolol failed to restore a good sympathovagal balance in hyperthyroidism. Trial registration NCT03393728 "Retrospectively registered"
Eliane Ngassam; Marcel Azabji-Kenfack; Aurel T. Tankeu; Liliane Mfeukeu-Kuate; Chris-Nadège Nganou-Gnindjio; Camille Mba; Jean Claude Katte; Mesmin Y. Dehayem; Jean Claude Mbanya; Eugène Sobngwi
Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study Article de journal
Dans: BMC Research Notes, vol. 11, iss. 1, p. 814, 2018, ISSN: 1756-0500.
Résumé | Liens | BibTeX | Étiquettes: Africa, Heart rate variability, Hyperthyroidism, Short-term
@article{Ngassam2018,
title = {Heart rate variability in hyperthyroidism on sub Saharan African patients: a case–control study},
author = {Eliane Ngassam and Marcel Azabji-Kenfack and Aurel T. Tankeu and Liliane Mfeukeu-Kuate and Chris-Nadège Nganou-Gnindjio and Camille Mba and Jean Claude Katte and Mesmin Y. Dehayem and Jean Claude Mbanya and Eugène Sobngwi},
url = {https://doi.org/10.1186/s13104-018-3922-4 https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3922-4},
doi = {10.1186/s13104-018-3922-4},
issn = {1756-0500},
year = {2018},
date = {2018-01-01},
journal = {BMC Research Notes},
volume = {11},
issue = {1},
pages = {814},
publisher = {BioMed Central},
abstract = {Objective: We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. HRV was assessed during each maneuver and on 24 h using a continuous electrocardiogram with automatic estimation of SDNN, RMSSD, LF HF and HF/LH ratio. Results of tests were compared between hyperthyroidism patients and matched controls using the non-parametric test of Mann-Whitney. Results: Heart rate was significantly higher in patients with thyrotoxicosis (82.91 ± 10.99 vs 67.04 ± 6.80; 0.006) compared to their controls. On time-domain analysis, there was a trend towards reduction in SDNN (39.52 vs. 63.75; p = 0.2) as well as the RMSSD (30.44 vs 64.03; p = 0.09) in patients with hyperthyroidism. The frequency-domain analysis showed non-significant higher values for the LF (43.87 vs 38.85 ± 12.85; p = 0.8) and lower for the HF (32.54 vs 43.39; p = 0.3). Test's results were mostly impaired in hyperthyroid patients and all patients presented abnormal results for parasympathetic activity. Untreated and recently diagnosed hyperthyroidism is associated to an altered parasympathetic activity in sub Saharan African patients.},
keywords = {Africa, Heart rate variability, Hyperthyroidism, Short-term},
pubstate = {published},
tppubtype = {article}
}
Objective: We aimed to determine heart rate variability in freshly diagnosed untreated hyperthyroidism patients. We enrolled 10 patients (9 females) and 10 matched controls for sex and age. Each eligible patient underwent five different tests according to Ewing battery tests for cardiac autonomic dysfunction assessment. HRV was assessed during each maneuver and on 24 h using a continuous electrocardiogram with automatic estimation of SDNN, RMSSD, LF HF and HF/LH ratio. Results of tests were compared between hyperthyroidism patients and matched controls using the non-parametric test of Mann-Whitney. Results: Heart rate was significantly higher in patients with thyrotoxicosis (82.91 ± 10.99 vs 67.04 ± 6.80; 0.006) compared to their controls. On time-domain analysis, there was a trend towards reduction in SDNN (39.52 vs. 63.75; p = 0.2) as well as the RMSSD (30.44 vs 64.03; p = 0.09) in patients with hyperthyroidism. The frequency-domain analysis showed non-significant higher values for the LF (43.87 vs 38.85 ± 12.85; p = 0.8) and lower for the HF (32.54 vs 43.39; p = 0.3). Test's results were mostly impaired in hyperthyroid patients and all patients presented abnormal results for parasympathetic activity. Untreated and recently diagnosed hyperthyroidism is associated to an altered parasympathetic activity in sub Saharan African patients.
Chris Nadège Nganou-Gnindjio; Camille Maadjhou Mba; Marcel Azabji-Kenfack; Mesmin Y. Dehayem; Liliane Mfeukeu-Kuate; Jean-Claude Mbanya; Eugène Sobngwi
Poor glycemic control impacts heart rate variability in patients with type 2 diabetes mellitus: a cross sectional study Article de journal
Dans: BMC Research Notes, vol. 11, iss. 1, p. 599, 2018, ISSN: 1756-0500.
Résumé | Liens | BibTeX | Étiquettes: Glycemic control, Heart rate variability, Type 2 diabetes patients
@article{Nganou-Gnindjio2018,
title = {Poor glycemic control impacts heart rate variability in patients with type 2 diabetes mellitus: a cross sectional study},
author = {Chris Nadège Nganou-Gnindjio and Camille Maadjhou Mba and Marcel Azabji-Kenfack and Mesmin Y. Dehayem and Liliane Mfeukeu-Kuate and Jean-Claude Mbanya and Eugène Sobngwi},
url = {https://doi.org/10.1186/s13104-018-3692-z https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3692-z},
doi = {10.1186/s13104-018-3692-z},
issn = {1756-0500},
year = {2018},
date = {2018-01-01},
journal = {BMC Research Notes},
volume = {11},
issue = {1},
pages = {599},
publisher = {BioMed Central},
abstract = {Objective: We aimed to determine and compare HRV parameters in poorly and well controlled type 2 diabetes. 54 normotensive type 2 diabetes patients without clinical signs of CAN were enrolled; 29 poorly controlled (HbA1c ≥ 7%) and 25 controls matched for age, sex and BMI. HRV analysis was performed using 24-h ambulatory ECG, with automatic estimation of the time and frequency domain ranges. Comparisons were performed using Mann-Whitney test. Results: We included 54 participants (26 males) aged 56 years [43-62], with known duration of diabetes 3 years [1-7]. HbA1c was 10.1% [9.1-11.9] vs 5.3% [5.1-6.3] (p < 0.001). Blood pressure was 126 mmHg [121-130] vs 124 mmHg [113-133] in the poorly controlled group and the well-controlled group respectively (p = 0.5). 24-h mean heart rate was significantly higher in poorly controlled vs well controlled patients (79 bpm [77-83] vs 75 bpm [69-79]},
keywords = {Glycemic control, Heart rate variability, Type 2 diabetes patients},
pubstate = {published},
tppubtype = {article}
}
Objective: We aimed to determine and compare HRV parameters in poorly and well controlled type 2 diabetes. 54 normotensive type 2 diabetes patients without clinical signs of CAN were enrolled; 29 poorly controlled (HbA1c ≥ 7%) and 25 controls matched for age, sex and BMI. HRV analysis was performed using 24-h ambulatory ECG, with automatic estimation of the time and frequency domain ranges. Comparisons were performed using Mann-Whitney test. Results: We included 54 participants (26 males) aged 56 years [43-62], with known duration of diabetes 3 years [1-7]. HbA1c was 10.1% [9.1-11.9] vs 5.3% [5.1-6.3] (p < 0.001). Blood pressure was 126 mmHg [121-130] vs 124 mmHg [113-133] in the poorly controlled group and the well-controlled group respectively (p = 0.5). 24-h mean heart rate was significantly higher in poorly controlled vs well controlled patients (79 bpm [77-83] vs 75 bpm [69-79]