2018
Aurel T. Tankeu; Marcel Azabji-Kenfack; Chris-Nadège Nganou; Eliane Ngassam; Liliane Kuate-Mfeukeu; Camille Mba; Mesmin Y. Dehayem; Jean-Claude Mbanya; Eugene Sobngwi
Effect of propranolol on heart rate variability in hyperthyroidism Article de journal
Dans: BMC Research Notes, vol. 11, iss. 1, p. 151, 2018, ISSN: 1756-0500.
Résumé | Liens | BibTeX | Étiquettes: Effect, Heart rate variability, Hyperthyroidism, Propranolol
@article{Tankeu2018,
title = {Effect of propranolol on heart rate variability in hyperthyroidism},
author = {Aurel T. Tankeu and Marcel Azabji-Kenfack and Chris-Nadège Nganou and Eliane Ngassam and Liliane Kuate-Mfeukeu and Camille Mba and Mesmin Y. Dehayem and Jean-Claude Mbanya and Eugene Sobngwi},
url = {https://doi.org/10.1186/s13104-018-3224-x https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-018-3224-x},
doi = {10.1186/s13104-018-3224-x},
issn = {1756-0500},
year = {2018},
date = {2018-01-01},
journal = {BMC Research Notes},
volume = {11},
issue = {1},
pages = {151},
publisher = {BioMed Central},
abstract = {Objectives: We aimed to determine the effect of propanolol on heart rate variability (HRV) in hyperthyroidism before antithyroid treatment. This was a before and after study, on ten patients presenting overt hyperthyroidism naïve to treatment. In each patient, a resting electrocardiogram was done followed by estimation of cardiac autonomic dysfunction during five maneuvers (Ewing battery tests). Long term HRV measurement was done using 24 h ambulatory electrocardiographic recording. This automatically provided estimation of HRV using SDNN and RMSSD index, LF, HF, and HF/LF ratio. After baseline investigations, 40 mg of propanolol was given twice a day for 3 days and same parameters were measured after 72 h of treatment. Results: Our patients were aged 40 ± 10 years. Propanolol significantly reduced RR and HR interval (669 ms vs 763 ms and 91 vs 79 bpm; p < 0.01). QT and PR space were significantly extended (360 vs 384 ms and 133 vs 172 ms; p = 0.01). It increases QRS complex and blood pressure response to sustained handgrip but failed to modify previously decreased heart response to deep breathing. HRV parameters such as SDNN, RMSSD, LF, HF and sympathovagal balance estimate by HF/LF ratio remained unchanged. Although a significant reduction in heart excitability, propanolol failed to restore a good sympathovagal balance in hyperthyroidism. Trial registration NCT03393728 "Retrospectively registered"},
keywords = {Effect, Heart rate variability, Hyperthyroidism, Propranolol},
pubstate = {published},
tppubtype = {article}
}
Objectives: We aimed to determine the effect of propanolol on heart rate variability (HRV) in hyperthyroidism before antithyroid treatment. This was a before and after study, on ten patients presenting overt hyperthyroidism naïve to treatment. In each patient, a resting electrocardiogram was done followed by estimation of cardiac autonomic dysfunction during five maneuvers (Ewing battery tests). Long term HRV measurement was done using 24 h ambulatory electrocardiographic recording. This automatically provided estimation of HRV using SDNN and RMSSD index, LF, HF, and HF/LF ratio. After baseline investigations, 40 mg of propanolol was given twice a day for 3 days and same parameters were measured after 72 h of treatment. Results: Our patients were aged 40 ± 10 years. Propanolol significantly reduced RR and HR interval (669 ms vs 763 ms and 91 vs 79 bpm; p < 0.01). QT and PR space were significantly extended (360 vs 384 ms and 133 vs 172 ms; p = 0.01). It increases QRS complex and blood pressure response to sustained handgrip but failed to modify previously decreased heart response to deep breathing. HRV parameters such as SDNN, RMSSD, LF, HF and sympathovagal balance estimate by HF/LF ratio remained unchanged. Although a significant reduction in heart excitability, propanolol failed to restore a good sympathovagal balance in hyperthyroidism. Trial registration NCT03393728 "Retrospectively registered"