Scientific papers

@article{Yako2018,

title = {Genetic factors contributing to hypertension in African-based populations: A systematic review and meta-analysis.},

author = {Yandiswa Y Yako and Eric V Balti and Tandi E Matsha and Anastase Dzudie and Deirdre Kruger and Eugene Sobngwi and Charles Agyemang and Andre P Kengne},

url = {http://www.ncbi.nlm.nih.gov/pubmed/29520984},

doi = {10.1111/jch.13225},

issn = {1751-7176},

year  = {2018},

date = {2018-01-01},

journal = {Journal of clinical hypertension (Greenwich, Conn.)},

volume = {20},

issue = {3},

pages = {485-495},

abstract = {In a systematic review, the authors explored genetic association studies of essential hypertension in African populations. Studies reporting on the association of polymorphism(s) with hypertension in African populations were included. Appropriate studies were pooled using random effects model meta-analysis, under six potential inheritance models. In all, 46 polymorphisms in 33 genes were investigated for their association with hypertension or blood pressure levels. Meta-analysis was possible for three single nucleotide polymorphisms: rs4340, rs699, and rs5186. An association was found between rs5186, rs699, and hypertension under allele contrast and homozygous codominant models (odds ratio, 1.63 [95% confidence interval, 1.04-2.54] and 4.01 [95% confidence interval, 1.17-13.80] for rs5186, respectively; and 1.80 [95% confidence interval, 1.13-2.87] for rs699). Findings were mostly robust in sensitivity analyses. According to the systematic review, there is currently insufficient evidence on the specific polymorphisms that pose the risk of hypertension in African populations. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms that may be specific to African populations.},

keywords = {Africa, blood pressure, diastolic, genetics, hypertension, systolic},

pubstate = {published},

tppubtype = {article}

}

@article{Lissock2011,

title = {Rural and urban differences in metabolic profiles in a Cameroonian population},

author = {CNAA Lissock and Eugène Sobngwi and Eliane Ngassam and LSE Ngoa},

url = {http://www.ajol.info/index.php/pamj/article/view/72204},

doi = {10.4314/pamj.v10i0.72204},

issn = {1937-8688},

year  = {2011},

date = {2011-01-01},

journal = {Pan African Medical Journal},

volume = {10},

pages = {1-15},

abstract = {Introduction: The difference between modern lifestyle in urban areas and the traditional way of life in rural areas may affect the population's health in developing countries proportionally. In this study, we sought to describe and compare the metabolic (fasting blood sugar and lipid profile) profile in an urban and rural sample of a Cameroonian population, and study the association to anthropometric risk factors of obesity. Methods: 332 urban and 120 rural men and women originating from the Sanaga Maritime Department and living in the Littoral Region in Cameroon voluntarily participated in this study. In all participants, measurement of height, weight, waist circumference, hip circumference, blood pressure systolic (SBP) and blood pressure diastolic (DBP), resting heart rate (RHR), blood glucose and lipids was carried out using standard methods. Total body fat (BF%) was measured using bio-impedancemetry. Body mass index (BMI) and waist to hip ratio (WHR) were calculated. Low Density Lipoprotein-cholesterol (LDL-c) concentrations were calculated using the Friedwald formula. World Health Organization criteria were used to define high and low levels of blood pressure, metabolic and anthropometric factors. Results: The highest blood pressure values were found in rural men. Concerning resting heart rate, only the youngest women's age group showed a significant difference between urban and rural areas (79 ± 14 bpm vs 88 ± 12 bpm},

keywords = {Adults, Anthropometry, Blood glucose, blood pressure, Cameroon, Diabetes, Lipid profile, Rural, Urban},

pubstate = {published},

tppubtype = {article}

}