2020
Eugene Sobngwi; Christine Ghislaine G Ngo Ngai; Martine Etoa Etoga; Eric Lontchi-Yimagou; Armand Mbanya; Mesmin Dehayem; Jean-Claude Mbanya
Use of capillary ketones monitoring in treatment of mild ketotic crisis in people with ketosis-prone atypical diabetes. Article de journal
Dans: Journal of investigative medicine : the official publication of the American Federation for Clinical Research, vol. 68, iss. 6, p. 1193-1195, 2020, ISSN: 1708-8267.
Résumé | Liens | BibTeX | Étiquettes: diabetes complications, diabetes mellitus, disease management
@article{Sobngwi2020,
title = {Use of capillary ketones monitoring in treatment of mild ketotic crisis in people with ketosis-prone atypical diabetes.},
author = {Eugene Sobngwi and Christine Ghislaine G Ngo Ngai and Martine Etoa Etoga and Eric Lontchi-Yimagou and Armand Mbanya and Mesmin Dehayem and Jean-Claude Mbanya},
url = {http://www.ncbi.nlm.nih.gov/pubmed/32665366},
doi = {10.1136/jim-2019-001267},
issn = {1708-8267},
year = {2020},
date = {2020-01-01},
journal = {Journal of investigative medicine : the official publication of the American Federation for Clinical Research},
volume = {68},
issue = {6},
pages = {1193-1195},
abstract = {This study was carried out to assess the potential reduction in duration of intensive diabetic ketoacidosis treatment in adults with ketosis-prone atypical diabetes (KPD) when using capillary versus urinary ketones. In this cross-sectional study, we included 20 people with KPD presented at the National Obesity Center of the Yaoundé Central Hospital with hyperglycemic decompensation (random capillary glucose ≥13 mmol/L) and significant ketosis (ketonuria≥++) requiring intensive insulin treatment. In all subjects, intensive insulin treatment was initiated at 10 UI per hour with simultaneous measurement of capillary beta-hydroxybutyrate and ketonuria every 2 hours until disappearance of ketonuria. Time-to-disappearance of urine ketones was compared with the time-to-normalization of capillary β-hydroxybutyrate concentrations. Subjects were aged 46±13 years with a median duration of diabetes of 1.5 (IQR: 0-2.5) years. On admission, the mean blood glucose was 22.8±5 mmol/L and capillary ketones level was 2.9±2.7 mmol/L. The median time-to-disappearance of ketonuria was 5 (IQR: 3-8) hours compared with the time-to-normalization of capillary β-hydroxybutyrate of 4 (IQR: 2-6) hours},
keywords = {diabetes complications, diabetes mellitus, disease management},
pubstate = {published},
tppubtype = {article}
}
This study was carried out to assess the potential reduction in duration of intensive diabetic ketoacidosis treatment in adults with ketosis-prone atypical diabetes (KPD) when using capillary versus urinary ketones. In this cross-sectional study, we included 20 people with KPD presented at the National Obesity Center of the Yaoundé Central Hospital with hyperglycemic decompensation (random capillary glucose ≥13 mmol/L) and significant ketosis (ketonuria≥++) requiring intensive insulin treatment. In all subjects, intensive insulin treatment was initiated at 10 UI per hour with simultaneous measurement of capillary beta-hydroxybutyrate and ketonuria every 2 hours until disappearance of ketonuria. Time-to-disappearance of urine ketones was compared with the time-to-normalization of capillary β-hydroxybutyrate concentrations. Subjects were aged 46±13 years with a median duration of diabetes of 1.5 (IQR: 0-2.5) years. On admission, the mean blood glucose was 22.8±5 mmol/L and capillary ketones level was 2.9±2.7 mmol/L. The median time-to-disappearance of ketonuria was 5 (IQR: 3-8) hours compared with the time-to-normalization of capillary β-hydroxybutyrate of 4 (IQR: 2-6) hours