Scientific papers

@article{Mba2019,

title = {Is PCSK9 Associated with Plasma Lipid Levels in a Sub-Saharan African Population of Patients with Obesity and Type 2 Diabetes?},

author = {Camille Maadjhou Mba and Wilfred Mbacham and Eugène Sobngwi and Jean Claude Mbanya},

url = {https://www.dovepress.com/is-pcsk9-associated-with-plasma-lipid-levels-in-a-sub-saharan-african–peer-reviewed-article-DMSO},

doi = {10.2147/DMSO.S234243},

issn = {1178-7007},

year  = {2019},

date = {2019-01-01},

journal = {Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy},

volume = {Volume 12},

pages = {2791-2797},

abstract = {Purpose: Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key regulator of circulating LDL cholesterol. There are inconsistent data in some populations concerning the association between PCSK9, LDL and CRP. The emerging importance of the inhibition of PCSK9 for the treatment of hypercholesterolemia warrants investigations in different populations. The aim of this study from a Sub-Saharan African population was to evaluate the association between PCSK9 and hs-CRP levels and plasma lipid levels in patients with type 2 diabetes (T2D) and obese and lean controls. Patients and methods: A cross-sectional analytical study was conducted in a major hospital in Yaoundé, Cameroon in a cohort of 162 participants (53% females). There were 54 non-obese T2D patients matched for age and sex to 54 obese nondiabetic and 54 nondiabetic lean subjects. PCSK9 level was assessed by sandwich ELISA method and hsCRP by nephelometry. Results: PCSK9 and hs-CRP levels were significantly higher in obese and T2D subjects when compared to lean controls (p<0.001 and p=0.002, respectively). The association between PCSK9 and triglyceride levels in the overall population was gender dependent (p=0.04) and subgroup analysis showed a significant positive correlation between PCSK9 and triglyceride levels in males but not in females (r=0.56},

keywords = {LDL-cholesterol, obesity, PCSK9, type 2 diabetes},

pubstate = {published},

tppubtype = {article}

}

@article{Nguimmo-Metsadjio2017,

title = {Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study},

author = {Aurelie Nguimmo-Metsadjio and Barbara Atogho-Tiedeu and Jean Jacques Noubiap and Marie-Solange Evehe and Rosine Djokam-Dadjeu and Olivier Sontsa Donfack and Dieudonne Nanfa and Edith Pascale M. Mato and Elvis Ndonwi Ngwa and Magellan Guewo-Fokeng and Priscille Pokam-Fosso and Wilfred F. Mbacham and Jean Claude Mbanya and Eugene Sobngwi},

url = {http://jhpn.biomedcentral.com/articles/10.1186/s41043-017-0087-z},

doi = {10.1186/s41043-017-0087-z},

issn = {2072-1315},

year  = {2017},

date = {2017-01-01},

journal = {Journal of Health, Population and Nutrition},

volume = {36},

issue = {1},

pages = {12},

publisher = {Journal of Health, Population and Nutrition},

abstract = {OBJECTIVE: This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the TCF7L2 gene with obesity in a Cameroonian population. METHOD: This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the TCF7L2 gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters. RESULTS: The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic (p = 0.50) and allelic frequencies (p = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups. CONCLUSION: The rs7903146 (C/T) polymorphism of the TCF7L2 gene might not be associated with obesity in the Cameroonian population.},

keywords = {Cameroon, Genetic association, obesity, rs7903146 (C/T) polymorphism, Sub-Saharan Africa, tcf7l2},

pubstate = {published},

tppubtype = {article}

}

@article{Mato2016,

title = {The Pro12Ala polymorphism in the PPAR-γ2 gene is not associated to obesity and type 2 diabetes mellitus in a Cameroonian population},

author = {Edith Pascale M. Mato and Priscille Eunice Pokam-Fosso and Barbara Atogho-Tiedeu and Jean Jacques N. Noubiap and Marie-Solange Evehe and Rosine Djokam-Dadjeu and Olivier Sontsa Donfack and Elvis Ndonwi Ngwa and Magellan Guewo-Fokeng and Wilfred F. Mbacham and Eugene Sobngwi and Jean Claude Mbanya},

url = {http://dx.doi.org/10.1186/s40608-016-0104-6 http://bmcobes.biomedcentral.com/articles/10.1186/s40608-016-0104-6},

doi = {10.1186/s40608-016-0104-6},

issn = {2052-9538},

year  = {2016},

date = {2016-01-01},

journal = {BMC Obesity},

volume = {3},

issue = {1},

pages = {26},

publisher = {BMC Obesity},

abstract = {Background: Peroxisome proliferator-activated receptor gamma 2 (PPAR-γ2) is a transcription factor with a key role in adipocyte differentiation, lipid storage and glucose homeostasis. The Ala allele of the common Pro12Ala polymorphism in the isoform PPAR-γ2 is at the center of many controversies because in some populations, it has been observed to be associated with T2DM or obesity but, not in others. The aim of this study was to investigate the association of Pro12Ala polymorphism in the PPAR-γ2 gene with susceptibility to obesity or T2DM in a Cameroonian population. Methods: This case-control study included 62 obese, 60 T2DM patients and 120 controls (60 non obese and 60 patients without T2DM), all unrelated and of Cameroonian origin. PPAR-γ2 was examined by genotyping for Pro12Ala using the Restriction Fragment Length Polymorphism - Polymerase Chain Reaction (PCR - RFLP). Results: A portion of the 270 base pair bands of the PPAR-γ2 gene was successfully amplified. The Ala12 variant was totally absent from the study population, all participants being homozygote Pro/Pro. Conclusion: PPAR-γ2 Pro12Ala gene polymorphism may not be associated with obesity and T2DM. These results suggest that, PPAR-γ2 is unlikely a major gene for obesity or T2DM in the study population.},

keywords = {Genetic association, obesity, PPAR gamma2, PPAR-γ2, Pro12Ala, Type 2 diabetes mellitus},

pubstate = {published},

tppubtype = {article}

}

@article{Ngwa2015a,

title = {Association between the rs12255372 variant of the TCF7L2 gene and obesity in a Cameroonian population},

author = {Elvis Ndonwi Ngwa and Eugene Sobngwi and Barbara Atogho-Tiedeu and Jean Jacques N. Noubiap and Olivier Sontsa Donfack and Magellan Guewo-Fokeng and Edith Pascale Mato Mofo and Priscille Pokam Fosso and Eric Djahmeni and Rosine Djokam-Dadjeu and Marie-Solange Evehe and Folefac Aminkeng and Wilfred F. Mbacham and Jean Claude Mbanya},

url = {http://www.biomedcentral.com/1756-0500/8/717},

doi = {10.1186/s13104-015-1661-3},

issn = {1756-0500},

year  = {2015},

date = {2015-01-01},

journal = {BMC Research Notes},

volume = {8},

issue = {1},

pages = {717},

publisher = {BioMed Central},

abstract = {Background: The transcription factor 7-like 2 (TCF7L2) is one of the genes that have been identified as possible determinants of diabetes which is associated with obesity. Data on the genetic causes of obesity in sub-Saharan African populations are very scares. The aim of this study was to assess the association between the transcription factor 7-like 2 (TCF7L2) gene polymorphism (rs12255372 G/T) and obesity and weight-related traits in a Cameroonian population. Methods: A case-control study was conducted on 35 obese and 30 non-obese Cameroonian adults. TCF7L2 rs12255372 genotypes were determined using PCR-RFLP and correlated with BMI and weight-related traits. Results: No significant association was observed between the rs12255372 T allele (χ2 = 0.0684},

keywords = {Cameroon, obesity, Sub-Saharan Africa, Transcription factor 7-like 2 (TCF7L2)},

pubstate = {published},

tppubtype = {article}

}

@article{AyinaAyina2015,

title = {Osteoprotegerin in relation to insulin resistance and blood lipids in sub-Saharan African women with and without abdominal obesity},

author = {Clarisse Noël Ayina Ayina and Eugene Sobngwi and Mickael Essouma and Jean Jacques N. Noubiap and Philippe Boudou and Laurent Serge Etoundi Ngoa and Jean François Gautier},

url = {??? http://www.dmsjournal.com/content/7/1/47},

doi = {10.1186/s13098-015-0042-3},

issn = {1758-5996},

year  = {2015},

date = {2015-01-01},

journal = {Diabetology & Metabolic Syndrome},

volume = {7},

issue = {1},

pages = {47},

publisher = {???},

abstract = {Background: Osteoprotegerin (OPG), a soluble member of the tumor necrosis factor receptor superfamily that inhibits bone resorption, has been suggested as a potential marker of cardiovascular risk. This study aimed to assess the relationship between insulin resistance, lipid profile and OPG levels in obese and non-obese sub-Saharan African women. Methods: Sixty obese (44) and non-obese (16) volunteer women aged 18 to 40 years were recruited in this cross-sectional study. Their clinical (age, height, weight, waist circumference, systolic and diastolic blood pressures) and biochemical parameters (fasting blood glucose, total cholesterol, high density lipoprotein-cholesterol (HDL-C)) were measured using standard methods. Insulin levels were measured using an electrochemiluminescence immunoassay, while OPG levels were measured using the ELISA technique. Low density lipoprotein-cholesterol (LDL-C), body mass index (BMI) and Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) were calculated using standard methods. Abdominal obesity was defined as a waist circumference ≥ 80 cm. Results: OPG levels were higher in obese than in normal subjects, though the difference was not significant (p = 0.9). BMI, waist circumference, percent body fat and systolic blood pressure were significantly higher in obese than in non-obese subjects (p < 0.05). In these subjects, only age significantly correlated with OPG levels (r = 0.831},

keywords = {insulin resistance, Lipids, obesity, Osteoprotegerin, Sub-Saharan Africans},

pubstate = {published},

tppubtype = {article}

}