2018
Eugene Sobngwi; Noel Désirée Mbango; Eric Vounsia Balti; Francoise Ngo Sack; Vicky Ama Moor; Jean-Claude Mbanya
Relative adrenal insufficiency in adults with sickle cell disease Article de journal
Dans: Pan African Medical Journal, vol. 29, p. 1-4, 2018, ISSN: 1937-8688.
Résumé | Liens | BibTeX | Étiquettes: Adrenal function, adult, cortisol, sickle cell disease, tetracosactide
@article{Sobngwi2018,
title = {Relative adrenal insufficiency in adults with sickle cell disease},
author = {Eugene Sobngwi and Noel Désirée Mbango and Eric Vounsia Balti and Francoise Ngo Sack and Vicky Ama Moor and Jean-Claude Mbanya},
url = {http://www.panafrican-med-journal.com/content/article/29/30/full/},
doi = {10.11604/pamj.2018.29.30.6025},
issn = {1937-8688},
year = {2018},
date = {2018-01-01},
journal = {Pan African Medical Journal},
volume = {29},
pages = {1-4},
abstract = {Rheological modifications observed in sickle cell anemia are associated with ischemic complications that can cause target organ functional impairment. The objective was to investigate adrenal function of adult patients with sickle cell disease. In this cross-sectional study conducted in a tertiary referral hospital of the capital city of Cameroon, we enrolled ten crisis-free adult patients with sickle cell disease (SCD) and ten age- and sex-matched healthy individuals. We assessed adrenal function by testing basal cortisol levels and 60 min after tetracosactide (Synacthen®) injection using immuno-chemiluminescence method. Post-stimulatory cortisol was defined as primary endpoint and secondary endpoints include basal cortisol levels, post-stimulatory cortisol increments and the fold increase of cortisol one hour after stimulation. Sickle cell patients had an impairment of adrenal function despite no significant difference between patients’ and controls’ for basal or post-stimulatory cortisol levels. In fact, one patient in two failed to achieve a two-fold increase in cortisol levels after stimulation (5/10) as opposed to 1 in 10 in the control population (1/10)},
keywords = {Adrenal function, adult, cortisol, sickle cell disease, tetracosactide},
pubstate = {published},
tppubtype = {article}
}
Rheological modifications observed in sickle cell anemia are associated with ischemic complications that can cause target organ functional impairment. The objective was to investigate adrenal function of adult patients with sickle cell disease. In this cross-sectional study conducted in a tertiary referral hospital of the capital city of Cameroon, we enrolled ten crisis-free adult patients with sickle cell disease (SCD) and ten age- and sex-matched healthy individuals. We assessed adrenal function by testing basal cortisol levels and 60 min after tetracosactide (Synacthen®) injection using immuno-chemiluminescence method. Post-stimulatory cortisol was defined as primary endpoint and secondary endpoints include basal cortisol levels, post-stimulatory cortisol increments and the fold increase of cortisol one hour after stimulation. Sickle cell patients had an impairment of adrenal function despite no significant difference between patients’ and controls’ for basal or post-stimulatory cortisol levels. In fact, one patient in two failed to achieve a two-fold increase in cortisol levels after stimulation (5/10) as opposed to 1 in 10 in the control population (1/10)