2018
Eric Lontchi-Yimagou; Jérôme Legoff; Jean-Louis Nguewa; Philippe Boudou; Eric V Balti; Jean J Noubiap; Vicky Kamwa; Barbara Atogho-Tiedeu; Marcel Azabji-Kenfack; Eric N Djahmeni; Martine Etoa; Gaelle Lemdjo; Vanessa Balla; Mesmin Y Dehayem; Fabienne Foufelle; Jean-Claude Mbanya; Jean-Francois Gautier; Eugene Sobngwi
Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes. Article de journal
Dans: Journal of diabetes, vol. 10, iss. 11, p. 866-873, 2018, ISSN: 1753-0407.
Résumé | Liens | BibTeX | Étiquettes: 2型糖尿病, 8型人类疱疹病毒, human herpesvirus type 8, insulin resistance, insulin secretion, ketosis-pronediabetes, type 2 diabetes, 胰岛素分泌, 胰岛素抵抗, 酮症倾向性糖尿病
@article{Lontchi-Yimagou2018a,
title = {Human herpesvirus 8 infection DNA positivity is associated with low insulin secretion: A case-control study in a sub-Saharan African population with diabetes.},
author = {Eric Lontchi-Yimagou and Jérôme Legoff and Jean-Louis Nguewa and Philippe Boudou and Eric V Balti and Jean J Noubiap and Vicky Kamwa and Barbara Atogho-Tiedeu and Marcel Azabji-Kenfack and Eric N Djahmeni and Martine Etoa and Gaelle Lemdjo and Vanessa Balla and Mesmin Y Dehayem and Fabienne Foufelle and Jean-Claude Mbanya and Jean-Francois Gautier and Eugene Sobngwi},
url = {http://www.ncbi.nlm.nih.gov/pubmed/29707905},
doi = {10.1111/1753-0407.12777},
issn = {1753-0407},
year = {2018},
date = {2018-01-01},
journal = {Journal of diabetes},
volume = {10},
issue = {11},
pages = {866-873},
abstract = {BACKGROUND Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes. METHODS In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment. RESULTS Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8- subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of β-cell function (HOMA-β) were significantly lower in DNA-HHV8+ than DNA-HHV8- participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8- (n = 85) subjects. In contrast, HOMA-β was significantly higher among Ac-HHV8+ than Ac-HHV8- participants. CONCLUSIONS In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.},
keywords = {2型糖尿病, 8型人类疱疹病毒, human herpesvirus type 8, insulin resistance, insulin secretion, ketosis-pronediabetes, type 2 diabetes, 胰岛素分泌, 胰岛素抵抗, 酮症倾向性糖尿病},
pubstate = {published},
tppubtype = {article}
}
BACKGROUND Viruses have been considered potential triggers for the development of diabetes. This study assessed insulin secretion and insulin sensitivity in human herpesvirus 8 (HHV8)-infected and uninfected sub-Saharan African people with diabetes. METHODS In all, 173 people with non-autoimmune diabetes were enrolled consecutively: 124 with type 2 diabetes mellitus (T2DM) and 49 with ketosis-prone diabetes (KPD) admitted in hyperglycemic crisis. Those with KPD were further subdivided into those with new-onset ketotic-phase KPD (n = 34) or non-ketotic phase KPD (n = 15). All participants were screened for HHV8-specific antibodies and genomic DNA. Blood samples were collected for analysis of fasting glucose, HbA1c, lipid profile, and C-peptide, with insulin resistance and secretion estimated by homeostasis model assessment. RESULTS Among the 173 diabetic participants, 88 (50.9%) were positive for HHV8 antibodies (Ac-HHV8+), including 15 (8.7%) positive for HHV8 DNA (DNA-HHV8+). The seroprevalence of HHV8 was similar between T2DM (55.6%) and KPD (61.2%) subjects. Of those with and without ketotic-phase KPD, 35.3% and 46.7% were Ac-HHV8+, respectively. Body mass index was significantly in lower DNA-HHV8+ than DNA-HHV8- subjects. Low-density lipoprotein and total cholesterol were significantly higher, but C-peptide and homeostatic model assessment of β-cell function (HOMA-β) were significantly lower in DNA-HHV8+ than DNA-HHV8- participants. After excluding DNA-HHV8+ participants, triglyceride concentrations were significantly higher in Ac-HHV8+ (n = 73) than Ac-HHV8- (n = 85) subjects. In contrast, HOMA-β was significantly higher among Ac-HHV8+ than Ac-HHV8- participants. CONCLUSIONS In the present study, HHV8 DNA positivity was associated with low insulin secretion in this sub-Saharan African diabetes population.